Eliminate time-consuming trial-and-error in method development.
Instead of optimizing conditions, simply extend the separation.
Purify difficult compounds with higher resolution, minimal sample loss, and reduced solvent use.
Recycling Preparative HPLC enables efficient purification of mg to gram scale samples with improved resolution, without increasing column length or solvent consumption.
Ideal for challenging separations such as isomers, oligomers, and closely related compounds — while making routine purification faster and easier.
What is Recycling Preparative HPLC?
Recycling HPLC is a technique in which the eluent is circulated through the column multiple times, effectively increasing the separation length without physically extending the column.
This allows higher resolution separations while maintaining a compact system size and minimizing solvent usage.
Key Advantages
Reduces time-consuming trial-and-error in method development
Enables simple, efficient, and reliable purification
Higher resolution without longer columns or additional solvent consumption
Minimizes sample loss through low-adsorption separation
Suitable for mg to gram scale purification
Typical Applications
Organic synthesis (isomer separation, reaction mixtures, small molecules)
Polymer and oligomer fractionation
Natural product purification
Medicinal chemistry and R&D purification
Functional materials and fine chemicals
Unique Separation Concept
Combines low-adsorption (GPC/SEC-based) separation with recycling for high recovery and resolution
Minimizes sample loss associated with adsorption-based purification
Ensures complete and reliable sample elution without unwanted retention
System & Performance
Dedicated recycling preparative HPLC systems (not modified analytical systems)
Optimized performance with JAIGEL column series
Proven track record in polymer, organic, and materials research
Flexible configurations from manual to fully automated systems
Enables precise fraction collection in both manual and automated operation
